Millie Hughes-Fulford, PhD

Professor

Education
Postdocteral, 1973 - Cholesterol Metabolilsm, Southwestern Medical School
PhD, 1972 - Radiation Chemistry and Biology, Texas Womans University
BS, 1968 - Chemistry and Biology, Tarleton State University
Honors and Awards
  • Named top outstanding research of ISS by NASA (, UCSF/NCIRE, 2013
  • NASA award for Best Flight Experiment "Mouse Immunology" STS-131, UCSF/NCIRE, 2011
  • NASA award for Best Flight Experiment "Mouse Immunology" STS-131, UCSF/NCIRE, 2011
  • VACO Secretary's Special Achievement Award, VAMCSF/UCSF, 1993-1996
  • VACO Secretary's Special Achievement Award, VAMCSF/UCSF, 1993-1996
  • NASA Space Flight Medal, UCSF, 1991
  • NASA Space Flight Medal, UCSF, 1991
  • Presidential Award of Federal Employee of the Year in Science, UCSF/VAMCSF, 1984
  • American Association of University Women Fellow/ MacArthur Foundation Fellow, TexasWomans University, 1971-1972
  • National Science Foundation Fellow (graduate, Texas Womans University, 1968-1971
  • National Science Foundation Undergraduate Research Fellow, Texas A&M, 1965-1966
Publications

  1. Bodden J, Sun D, Joseph GB, Huang LW, Andreadis C, Hughes-Fulford M, Lang TF, Link TM. Identification of non-Hodgkin lymphoma patients at risk for treatment-related vertebral density loss and fractures. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2020. PMID: 32803319


  2. Richard Boyle, Millie Hughes-Fulford. Space Biology (Cells to Amphibians). Encyclopedia of Bioastronautics 2019. PMID:


  3. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). Journal of the American Heart Association 2015. PMID: 26296857


  4. Hughes-Fulford M, Chang TT, Martinez EM, Li CF. Spaceflight alters expression of microRNA during T-cell activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015. PMID: 26276131


  5. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015. PMID: 26085131


  6. Martinez EM, Yoshida MC, Candelario TL, Hughes-Fulford M. Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. American journal of physiology. Regulatory, integrative and comparative physiology 2015. PMID: 25568077


  8. Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vascular medicine (London, England) 2013. PMID: 24052491


  9. Marlene Grenon, Christopher D. Owens, Hugh Alley, Karen Chong, Eric Vittinghoff, William Harris, Millie Hughes-Fulford, Joseph Rapp, Michael Conte. The Association Between Erythrocyte n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Content and Inflammation in Male Patients With Peripheral Artery Disease (PAD). Journal of vascular surgery 2013. PMID:


  10. S. Grenon, M. Jeanne, M.S. Conte, M. Hughes-Fulford. Effects of Mechanical Gravitational Unloading on Vascular Endothelial Cells Function. Journal of Surgical Research 2013. PMID:


  11. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Scientific reports 2013. PMID: 23511048


  12. Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M. Can I take a space flight? Considerations for doctors. BMJ (Clinical research ed.) 2012. PMID: 23241271


  13. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. Journal of leukocyte biology 2012. PMID: 22750545


  14. Marlene Grenon, Jesus Aguado-Zunega, Michael S. Conte, Millie Hughes-Fulford. PS204. Mechanical (or “Gravitational”) Unloading Reduces Inflammatory and Cell Adhesion Molecule Gene Expression in Human Endothelial Cells. Journal of vascular surgery 2012. PMID:


  15. Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. The Journal of surgical research 2012. PMID: 22572621


  16. Grenon SM, Hughes-Fulford M, Rapp J, Conte MS. Polyunsaturated fatty acids and peripheral artery disease. Vascular medicine (London, England) 2012. PMID: 22363018


  17. S.M. Grenon, J. Aguado-Zuniga, M.S. Conte, M. Hughes-Fulford. The Effects of Polyunsaturated Fatty Acids on Monocyte-Endothelial Cell Interactions. Journal of Surgical Research 2012. PMID:


  18. Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PloS one 2011. PMID: 21912659


  19. Hughes-Fulford M. To infinity ... and beyond! Human spaceflight and life science. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 21880668


  20. Hughes-Fulford M, Li CF. The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. Journal of orthopaedic surgery and research 2011. PMID: 21306641


  21. Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR. Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer causes & control : CCC 2010. PMID: 21103921


  23. C.-F. Li, J. C. Bodle, J. P. Hatton, M. Hughes-Fulford. ACTIVATION AND REGULATION OF SIGNAL TRANSDUCTION IN MONOCYTES AND THEIR CORRELATION WITH GRAVITY.: 278. Journal of Investigative Medicine 2007. PMID:


  24. Sevigny MB, Li CF, Alas M, Hughes-Fulford M. Glycosylation regulates turnover of cyclooxygenase-2. FEBS letters 2006. PMID: 17113084


  25. Hughes-Fulford M, Rodenacker K, Jütting U. Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. Journal of cellular biochemistry 2006. PMID: 16619267


  26. Li CF, Hughes-Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006. PMID: 16753025


  27. Mary B. Sevigny, Millie Hughes-Fulford. Differential glycosylation regulates turnover of cyclooxygenase-2. The FASEB Journal 2006. PMID:


  28. Hughes-Fulford M, Li CF, Boonyaratanakornkit J, Sayyah S. Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer research 2006. PMID: 16452198


  29. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005. PMID: 16210397


  30. Hughes-Fulford M, Tjandrawinata RR, Li CF, Sayyah S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis 2005. PMID: 15878913


  31. Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. Early immune response and regulation of IL-2 receptor subunits. Cellular signalling 2005. PMID: 15993752


  32. Hughes-Fulford M. Signal transduction and mechanical stress. Science's STKE : signal transduction knowledge environment 2004. PMID: 15353762


  33. Hughes-Fulford M. Lessons learned about spaceflight and cell biology experiments. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 2004. PMID: 16145818


  34. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003. PMID: 12510806


  35. Hughes-Fulford M. Function of the cytoskeleton in gravisensing during spaceflight. Advances in space research : the official journal of the Committee on Space Research (COSPAR) 2003. PMID: 15002415


  36. Hughes-Fulford M. The role of signaling pathways in osteoblast gravity perception. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 2002. PMID: 15002570


  37. Hughes-Fulford M. Physiological effects of microgravity on osteoblast morphology and cell biology. Advances in space biology and medicine 2002. PMID: 12951695


  38. Hughes-Fulford M. Changes in gene expression and signal transduction in microgravity. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 2001. PMID: 12638602


  39. Hughes-Fulford M, Chen Y, Tjandrawinata RR. Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis 2001. PMID: 11323387


  40. Chen Y, Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. International journal of cancer 2001. PMID: 11149418


  42. Lewis ML, Hughes-Fulford M. Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions. Journal of cellular biochemistry 2000. PMID: 10679823


  45. Fitzgerald J, Hughes-Fulford M. Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999. PMID: 10064622


  46. Hughes-Fulford M, Gilbertson V. Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999. PMID: 10352153


  47. Hughes-Fulford M, Tjandrawinata R, Fitzgerald J, Gasuad K, Gilbertson V. Effects of microgravity on osteoblast growth. Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 1998. PMID: 11540639


  48. Tjandrawinata RR, Vincent VL, Hughes-Fulford M. Vibrational force alters mRNA expression in osteoblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997. PMID: 9194530


  49. Hughes-Fulford M, Boman B. Growth regulation of Gardner's syndrome colorectal cancer cells by NSAIDs. Advances in experimental medicine and biology 1997. PMID: 9321987


  50. Tjandrawinata RR, Dahiya R, Hughes-Fulford M. Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. British journal of cancer 1997. PMID: 9099957


  51. Hughes-Fulford M. Prostaglandin regulation of gene expression and growth in normal and malignant tissues. Advances in experimental medicine and biology 1997. PMID: 9547568


  52. Tjandrawinata RR, Hughes-Fulford M. Up-regulation of cyclooxygenase-2 by product-prostaglandin E2. Advances in experimental medicine and biology 1997. PMID: 9321948


  53. Fitzgerald J, Hughes-Fulford M. Gravitational loading of a simulated launch alters mRNA expression in osteoblasts. Experimental cell research 1996. PMID: 8892985


  54. Leong J, Hughes-Fulford M, Rakhlin N, Habib A, Maclouf J, Goldyne ME. Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. Experimental cell research 1996. PMID: 8612694


  55. Hughes-Fulford M, Lewis ML. Effects of microgravity on osteoblast growth activation. Experimental cell research 1996. PMID: 8612673


  57. Lin HS, Hughes-Fulford M, Kumegawa M, Pitts AC, Snowdowne KW. Cytoplasmic pH influences cytoplasmic calcium in MC3T3-E1 osteoblast cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993. PMID: 8328315


  58. Hughes-Fulford M, Fukushima M. Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism. Life science advances. Experimental and clinical endocrinology : a journal of the Council of Scientific Research Integration 1993. PMID: 11539936


  59. Millie Hughes-Fulford. Growth and Repair of Mineralized Osteoblasts. Spinal Instability 1993. PMID:


  62. Hughes-Fulford M, McGrath MS, Hanks D, Erickson S, Pulliam L. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrobial agents and chemotherapy 1992. PMID: 1332592


  63. Rossberg Walker K, Hughes-Fulford M, Schmidt G. KC-135 flights for life science activities. ASGSB bulletin : publication of the American Society for Gravitational and Space Biology 1992. PMID: 11537651


  64. Millie Hughes-Fulford. Growth and Repair of Mineralized Osteoblasts. Clinical Spine Surgery 1992. PMID:


  65. Hughes-Fulford M. Altered cell function in microgravity. Experimental gerontology 1991. PMID: 1915694


  66. Demeure MJ, Hughes-Fulford M, Goretzki PE, Duh QY, Clark OH. Actin architecture of cultured human thyroid cancer cells: predictor of differentiation? Surgery 1990. PMID: 2247845


  67. A. E. Siperstein, H. van Raavenswaay Claasen, R. Miller, M. M. Bhattathiry, M. Hughes-Fulford, O. H. Clark. Thyroid-Stimulating Hormone Growth-Responsive, Cyclic Adenosine Monophosphate-Unresponsive Poorly Differentiated Thyroid Carcinoma of Follicular Cell Origin1. Growth Regulation of Thyroid Gland and Thyroid Tumors 1989. PMID:


  68. Hughes-Fulford M, Scheld HW. Thin film bioreactors in space. Advances in space research : the official journal of the Committee on Space Research (COSPAR) 1989. PMID: 11537324


  69. Erickson SK, Cooper AD, Barnard GF, Havel CM, Watson JA, Feingold KR, Moser AH, Hughes-Fulford M, Siperstein MD. Regulation of cholesterol metabolism in a slow-growing hepatoma in vivo. Biochimica et biophysica acta 1988. PMID: 2835108


  70. M. Hughes-Fulford. The Mechanism of Prostaglandin Inhibition on the Cell Cycle. Prostaglandins in Cancer Research 1987. PMID:


  71. Hughes-Fulford M, Feingold KR, Searle GL, Wu J, Siperstein MD, Schoenfeld PY, Kaysen G. Role of the kidneys in the metabolism of circulating mevalonate in humans. The Journal of clinical endocrinology and metabolism 1986. PMID: 3084536


  72. Feingold KR, Zsigmond G, Hughes-Fulford M, Lear SR, Moser AH. The effect of diabetes mellitus on the lymphatic transport of intestinal sterols. Metabolism: clinical and experimental 1985. PMID: 4069009


  73. Williams ML, Hughes-Fulford M, Elias PM. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and sterol synthesis by cholesterol sulfate in cultured fibroblasts. Biochimica et biophysica acta 1985. PMID: 3859337


  74. Hughes-Fulford M, Wu J, Kato T, Fukushima M. Inhibition of DNA synthesis and cell cycle by prostaglandins independent of cyclic AMP. Advances in prostaglandin, thromboxane, and leukotriene research 1985. PMID: 3004144


  75. Trentalance A, Leoni S, Mangiantini MT, Spagnuolo S, Feingold K, Hughes-Fulford M, Siperstein M, Cooper AD, Erickson SK. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regeneration. Biochimica et biophysica acta 1984. PMID: 6733123