Elizabeth Murphy, MD, PhD

Professor

Elizabeth Murphy, MD, DPhil, is Chief of the Endocrinology and Metabolism Division, Director of the Diabetes Center for High Risk Populations and Specialty Lead of the eReferral Program at San Francisco General Hospital and a Professor of Clinical Medicine at the University of California, San Francisco.

As Chief of the Endocrinology and Metabolism Division at SFGH, Dr. Murphy's work has focused on improving access and quality of endocrinology and diabetes care for low income, diverse populations in the San Francisco safety net. As Director of the Diabetes Center for High Risk Populations, she has led the development of novel services such as medical group visits for insulin initiation in English and Spanish, low literacy insulin teaching aids for patients, medication management algorithms for primary care, and targeted outreach to SF County Jail patients. Her team’s efforts in health disparities were recognized by the American Diabetes Association’s Promising Practice Award of Excellence in 2012 and were an integral part of the Healthy San Francisco Chronic Care Redesign Program recognized by the National Association of Public Hospitals’ Safety Net Award in 2010.

Through her work as Specialty Lead of the eReferral program, Dr. Murphy has been instrumental in standardizing the role of the specialist reviewer with an emphasis on improving primary-specialty care communication. In addition she has worked with the Endocrine Society on improving the referral process as part of the ACP High Value Care Coordination Project.

Previously, Dr. Murphy served as the Chief Medical Officer of KineMed, Inc, a biotechnology company focused on the use of stable isotope technology to measure kinetic processes for drug development. There she was responsible for in vivo human studies in diverse areas including insulin resistance and diabetes, lipid metabolism, chronic lymphocytic leukemia, prostate cancer, and bile acid kinetics.

A practicing endocrinologist, Dr. Murphy received the UCSF/San Francisco General Hospital Department of Medicine Subspecialty Consultant of the Year Award in 2011, the John Karum Clinician Educator Award in 2011 for her work with UCSF endocrinology fellows and in 2015 was named a Master Clinician in the Department of Medicine.

Dr. Murphy received her BA in Chemistry from Wellesley College, a D.Phil. in Biochemistry from Oxford University as a Rhodes Scholar, and MD from Harvard Medical School in the Harvard-MIT affiliated Health Sciences and Technology program. She completed her internal medicine residency and endocrinology fellowship training at UCSF.
Education
2021 - Diversity Equity and Inclusion Champion Training, University of California
Fellowship, 2002 - Endocrinology and Metabolism, University of California, San Francisco
Internship and Residency, 1997 - Internal Medicine, University of California, San Francisco
M.D., 1994 - School of Medicine, Harvard University
DPhil, 1989 - Biochemistry, Oxford University
BA, 1986 - Chemistry, Wellesley College
Websites
Publications
  1. Kim S, Conrad M, Chuang E, Cai L, Masharani U, Murphy EJ. Calcium Stimulation Test for Insulinoma Localization in an End-stage Renal Disease Patient on Diazoxide. 2020. PMID: 33381673


  2. Marpadga S, Fernandez A, Leung J, Tang A, Seligman H, Murphy EJ. Challenges and Successes with Food Resource Referrals for Food-Insecure Patients with Diabetes. 2019. PMID: 30939269


  3. Tuot DS, Liddy C, Vimalananda VG, Pecina J, Murphy EJ, Keely E, Simon SR, North F, Orlander JD, Chen AH. Evaluating diverse electronic consultation programs with a common framework. 2018. PMID: 30355346


  4. Beysen C, Ruddy M, Stoch A, Mixson L, Rosko K, Riiff T, Turner SM, Hellerstein MK, Murphy EJ. Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans. 2018. PMID: 29558206


  5. Saslow LR, Daubenmier JJ, Moskowitz JT, Kim S, Murphy EJ, Phinney SD, Ploutz-Snyder R, Goldman V, Cox RM, Mason AE, Moran P, Hecht FM. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. 2017. PMID: 29269731


  6. Kwok J, Olayiwola JN, Knox M, Murphy EJ, Tuot DS. Electronic consultation system demonstrates educational benefit for primary care providers. 2017. PMID: 28614974


  7. Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ. Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study. 2017. PMID: 28713554


  8. Kuo CR, Quan J, Kim S, Tang AH, Heuerman DP, Murphy EJ. Group visits to encourage insulin initiation: targeting patient barriers. 2017. PMID: 27602873


  9. Murphy EJ, Neuberg DS, Rassenti LZ, Hayes G, Redd R, Emson C, Li K, Brown JR, Wierda WG, Turner S, Greaves AW, Zent CS, Byrd JC, McConnel C, Barrientos J, Kay N, Hellerstein MK, Chiorazzi N, Kipps TJ, Rai KR. Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia. 2017. PMID: 28115735


  10. Tuvdendorj D, Munoz AO, Ruiz-Barros V, Schwarz JM, Montalto G, Chandalia M, Sowers LC, Rizzo M, Murphy EJ, Abate N. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters. 2016. PMID: 27323227


  11. Marshall NE, Murphy EJ, King JC, Haas EK, Lim JY, Wiedrick J, Thornburg KL, Purnell JQ. Comparison of multiple methods to measure maternal fat mass in late gestation. 2016. PMID: 26888714


  12. Tuot DS, Leeds K, Murphy EJ, Sarkar U, Lyles CR, Mekonnen T, Chen AH. Facilitators and barriers to implementing electronic referral and/or consultation systems: a qualitative study of 16 health organizations. 2015. PMID: 26687507


  13. Epstein AE, Olshansky B, Naccarelli GV, Kennedy JI, Murphy EJ, Goldschlager N. Practical Management Guide for Clinicians Who Treat Patients with Amiodarone. 2015. PMID: 26497904


  14. Stern RJ, Murphy EJ. Metformin as Initial Oral Therapy in Type 2 Diabetes. 2015. PMID: 26103032


  15. Tuot DS, Murphy EJ, McCulloch CE, Leeds K, Chan E, Chen AH. Leveraging an electronic referral system to build a medical neighborhood. 2015. PMID: 26699344


  16. McDermott KA, Rao MR, Nagarathna R, Murphy EJ, Burke A, Nagendra RH, Hecht FM. A yoga intervention for type 2 diabetes risk reduction: a pilot randomized controlled trial. 2014. PMID: 24980650


  17. Saslow LR, Kim S, Daubenmier JJ, Moskowitz JT, Phinney SD, Goldman V, Murphy EJ, Cox RM, Moran P, Hecht FM. A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes. 2014. PMID: 24717684


  18. Tuvdendorj D, Chandalia M, Batbayar T, Saraf M, Beysen C, Murphy EJ, Abate N. Altered subcutaneous abdominal adipose tissue lipid synthesis in obese, insulin-resistant humans. 2013. PMID: 23982159


  19. Chen AH, Murphy EJ, Yee HF. eReferral--a new model for integrated care. 2013. PMID: 23802515


  20. Turner S, Voogt J, Davidson M, Glass A, Killion S, Decaris J, Mohammed H, Minehira K, Boban D, Murphy E, Luchoomun J, Awada M, Neese R, Hellerstein M. Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion. 2012. PMID: 23130164


  21. Hayes GM, Simko J, Holochwost D, Kuchinsky K, Busch R, Misell L, Murphy EJ, Carroll P, Chan J, Shinohara K, Hellerstein MK. Regional cell proliferation in microdissected human prostate specimens after heavy water labeling in vivo: correlation with prostate epithelial cells isolated from seminal fluid. 2012. PMID: 22553345


  22. Beysen C, Murphy EJ, Deines K, Chan M, Tsang E, Glass A, Turner SM, Protasio J, Riiff T, Hellerstein MK. Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. 2011. PMID: 22134839


  23. Wilson JP, Mulligan K, Fan B, Sherman JL, Murphy EJ, Tai VW, Powers CL, Marquez L, Ruiz-Barros V, Shepherd JA. Dual-energy X-ray absorptiometry-based body volume measurement for 4-compartment body composition. 2011. PMID: 22134952


  24. Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. 2011. PMID: 21968788


  25. Brufau G, Stellaard F, Prado K, Bloks VW, Jonkers E, Boverhof R, Kuipers F, Murphy EJ. Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. 2010. PMID: 20725912


  26. Brufau G, Bahr MJ, Staels B, Claudel T, Ockenga J, Böker KH, Murphy EJ, Prado K, Stellaard F, Manns MP, Kuipers F, Tietge UJ. Plasma bile acids are not associated with energy metabolism in humans. 2010. PMID: 20815878


  27. Stellaard F, Bloks VW, Burgerhof HG, Scheltema RA, Murphy EJ, Romijn HA, Smelt GH, Brufau G, Kuipers F. Two time-point assessment of bile acid kinetics in humans using stable isotopes. 2010. PMID: 20645205


  28. Sarkar U, Handley MA, Gupta R, Tang A, Murphy E, Seligman HK, Shojania KG, Schillinger D. What happens between visits? Adverse and potential adverse events among a low-income, urban, ambulatory population with diabetes. 2010. PMID: 20378619


  29. Cheng MH, Fan U, Grewal N, Barnes M, Mehta A, Taylor S, Husebye ES, Murphy EJ, Anderson MS. Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect. Volume 362 of Issue 8. 2010. PMID: 20181983


  30. Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, Moreno C, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. 2009. PMID: 19789386


  31. Beysen C, Murphy EJ, Nagaraja H, Decaris M, Riiff T, Fong A, Hellerstein MK, Boyle PJ. A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes. 2008. PMID: 18641372


  32. Sarkar U, Handley MA, Gupta R, Tang A, Murphy E, Seligman HK, Shojania KG, Schillinger D. Use of an interactive, telephone-based self-management support program to identify adverse events among ambulatory diabetes patients. 2008. PMID: 18373145


  33. Goldschlager N, Epstein AE, Naccarelli GV, Olshansky B, Singh B, Collard HR, Murphy E. A practical guide for clinicians who treat patients with amiodarone: 2007. 2007. PMID: 17765636


  34. Beysen C, Murphy EJ, McLaughlin T, Riiff T, Lamendola C, Turner HC, Awada M, Turner SM, Reaven G, Hellerstein MK. Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo. 2007. PMID: 17259480


  35. Turner SM, Roy S, Sul HS, Neese RA, Murphy EJ, Samandi W, Roohk DJ, Hellerstein MK. Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. 2006. PMID: 17164440


  36. Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy EJ, Koduru P, Ferrarini M, Zupo S, Cutrona G, Damle RN, Wasil T, Rai KR, Hellerstein MK, Chiorazzi N. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. 2005. PMID: 15711642


  37. Turner SM, Murphy EJ, Neese RA, Antelo F, Thomas T, Agarwal A, Go C, Hellerstein MK. Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA. 2003. PMID: 12824084


  38. Murphy EJ, Davern TJ, Shakil AO, Shick L, Masharani U, Chow H, Freise C, Lee WM, Bass NM. Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group. 2000. PMID: 10749332


  39. Murphy EJ. Doctor discontent. 1999. PMID: 10049079


  40. Murphy EJ, Bates TE, Williams SR, Watson T, Brindle KM, Rajagopalan B, Radda GK. Endoplasmic reticulum: the major contributor to the PDE peak in hepatic 31P-NMR spectra at low magnetic field strengths. 1992. PMID: 1390864


  41. Murphy EJ, Brindle KM, Rorison CJ, Dixon RM, Rajagopalan B, Radda GK. Changes in phosphatidylethanolamine metabolism in regenerating rat liver as measured by 31P-NMR. 1992. PMID: 1591270


  42. Murphy EJ, Rajagopalan B, Brindle KM, Radda GK. Phospholipid bilayer contribution to 31P NMR spectra in vivo. 1989. PMID: 2559292


  43. Kolodny NH, Gragoudas ES, D'Amico DJ, Seddon JM, Minichiello M, Murphy EJ, Albert DM. Preliminary results on phosphorus-31 nuclear magnetic resonance evaluation of human uveal melanoma in enucleated eyes. 1988. PMID: 3174026


  44. Kolodny NH, Gragoudas ES, D'Amico DJ, Kohler SJ, Seddon JM, Murphy EJ, Yun C, Albert DM. Proton and sodium 23 magnetic resonance imaging of human ocular tissues. A model study. 1987. PMID: 2823760


  45. Richards TL, Keniry MA, Weinstein PR, Pereira BM, Andrews BT, Murphy EJ, James TL. Measurement of lactate accumulation by in vivo proton NMR spectroscopy during global cerebral ischemia in rats. 1987. PMID: 3683164