Dolores Shoback, MD

Professor

Dr. Dolores Shoback cares for patients with a variety of disorders related to the endocrine system, focusing particularly on metabolic bone disease, parathyroid disorders and osteoporosis. She also directs UCSF's physician training program in diabetes, endocrinology and metabolism.

Shoback's research interests include metabolic bone disease, the calcium-sensing receptor and parathyroid hormone.

Shoback completed her undergraduate studies at the University of Pennsylvania. She earned her medical degree from the Johns Hopkins School of Medicine and completed a residency in internal medicine at the Johns Hopkins Hospital. She completed a fellowship in endocrinology at Brigham and Women's Hospital.
Education
M.D., 1977 - School of Medicine, Johns Hopkins
Publications

  1. Riggles KE, Brubeck HF, Tanus AD, Loecker CN, Roul P, England BR, Wahl ER, Andrews JS, Singh N, Baker JF, Katz PP, Shoback DM, Garcia JM, Orkaby AR, Wysham KD. Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis. Arthritis care & research 2026. PMID: 41656584


  2. Wysham KD, Brubeck HF, Baraff A, Roul P, Olave M, Richards JS, Monach P, Shoback DM, Katz PP, Sauer BC, Wallace B, Garcia JM, Cannon GW, Mikuls TR, England BR, Baker JF. High disease activity is associated with incident osteoporotic fractures among veterans with rheumatoid arthritis. Joint bone spine 2025. PMID: 41419188


  3. Bhide SA, Roul P, England BR, Brubeck HF, Cannon GW, Singh N, Loecker C, Kunkel G, Mikuls TR, Shoback DM, Michaud K, Katz PP, Garcia JM, Orkaby AR, Baker JF, Wysham KD. Frailty carries an increased risk of death in rheumatoid arthritis. Seminars in arthritis and rheumatism 2025. PMID: 41232460


  4. Dawood R, Brubeck HF, Riggles KE, Sattui SE, Myasoedova E, Makris UE, Shoback DM, Garcia JM, Orkaby AR, Baker JF, Katz PP, Wysham KD. Exploring Factors Associated With Cognitive Impairment in Rheumatoid Arthritis. Arthritis care & research 2025. PMID: 41147773


  5. Graham T, Shoback DM, Abbott L, Lubitz S, Edelson G, Haider A, Ing SW, Rothman MS, Cusano NE, Zhao C, Ukena J, Schneider M, Sibley CT, Rubin MR. Early U.S. Real-World Treatment Patterns and Outcomes in Palopegteriparatide Treatment for Patients With Hypoparathyroidism. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2025. PMID: 40846304


  6. Brubeck HF, Riggles KE, Bass RS, Wahl ER, Mount G, Shoback DM, Andrews JS, Garcia JM, Orkaby AR, Baker JF, Katz PP, Wysham KD, Loecker CN. Evaluating the Longitudinal Association of Rheumatoid Arthritis Disease Activity with Phenotypic Frailty: Evidence for Secondary Frailty? Arthritis care & research 2025. PMID: 40702741


  7. Khan AA, Ali DS, Bilezikian JP, Björnsdottir S, Collins MT, Cusano NE, Ebeling PR, Fuleihan GEH, Fukumoto S, Giustina A, Kaiser SM, Koch CA, Khan T, Keating P, Liu JM, Mantzoros CS, Mannstadt M, Mithal A, Perrier ND, Rayes M, Rizzoli R, Rhee Y, Rubin MR, Roszko KL, Shrayyef M, Shoback DM, Sikjær T, Siggelkow H, Sfeir J, Thakker R, Van Uum S, Winer KK, Yavuz DG, Yildiz BO, AbuAlrob H, Brandi ML. Best practice recommendations for the diagnosis and management of hypoparathyroidism. Metabolism: clinical and experimental 2025. PMID: 40581321


  8. Brandi ML, Pieterman CRC, English KA, Lines KE, Shariq OA, Marini F, Cuny T, Lewis MA, Stratakis CA, Perrier ND, Waguespack SG, Castinetti F, Valk GD, Thakker RV, Delphi Expert Panel. Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice. The lancet. Diabetes & endocrinology 2025. PMID: 40523372


  9. Tu CL, Cheng Z, Szeto N, Savransky S, Glinin T, Shoback DM, Sosa JA, Vilardaga JP, Koh J, Chang W. β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism. medRxiv : the preprint server for health sciences 2025. PMID: 40492090


  10. Clarke BL, Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Abbott LG, Hofbauer LC, Kohlmeier L, Cetani F, Pihl S, An X, Smith AR, Lai B, Ukena J, Sibley CT, Shu AD, Rejnmark L. Efficacy and Safety of TransCon PTH in Adults with Hypoparathyroidism: 52-Week Results From the Phase 3 PaTHway Trial. The Journal of clinical endocrinology and metabolism 2024. PMID: 39376010


  11. Rejnmark L, Gosmanova EO, Khan AA, Makita N, Imanishi Y, Takeuchi Y, Sprague S, Shoback DM, Kohlmeier L, Rubin MR, Palermo A, Schwarz P, Gagnon C, Tsourdi E, Zhao C, Makara MA, Ominsky MS, Lai B, Ukena J, Sibley CT, Shu AD. Palopegteriparatide Treatment Improves Renal Function in Adults with Chronic Hypoparathyroidism: 1-Year Results from the Phase 3 PaTHway Trial. Advances in therapy 2024. PMID: 38691316


  12. Faiq S, Lavelle K, Hu T, Shoback D, Ku G. Cinacalcet increases renal calcium excretion in PTHrP-mediated hypercalcemia: a case report. BMC endocrine disorders 2023. PMID: 37328745


  13. Watts NB, Bilezikian JP, Bone HG, Clarke BL, Denham D, Levine MA, Mannstadt M, Peacock M, Rothman JG, Vokes TJ, Warren ML, Yin S, Sherry N, Shoback DM. Long-Term Safety and Efficacy of Recombinant Human Parathyroid Hormone (1-84) in Adults With Chronic Hypoparathyroidism. Journal of the Endocrine Society 2023. PMID: 37091306


  14. Shen WT, Kebebew E, Shoback D, Liu C, Gosnell JE, Caron NR. In Memoriam: Orlo H. Clark, MD (1941-2022). Thyroid : official journal of the American Thyroid Association 2023. PMID: 36719769


  15. Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36153665


  16. Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, Mannstadt M. Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36054621


  17. Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Marcocci C, Clarke BL, Abbott LG, Hofbauer LC, Kohlmeier L, Pihl S, An X, Eng WF, Smith AR, Ukena J, Sibley CT, Shu AD, Rejnmark L. Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022. PMID: 36271471


  18. Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL. Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery. Bone reports 2022. PMID: 35734226


  19. Wysham KD, Shofer J, Lui G, Trupin L, Andrews JS, Black DM, Graf J, Shoback DM, Katz PP. Low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort. AACE Clinical Case Reports 2022. PMID: 35152085


  20. Seib CD, Meng T, Suh I, Harris AHS, Covinsky KE, Shoback DM, Trickey AW, Kebebew E, Tamura MK. Risk of Fracture Among Older Adults With Primary Hyperparathyroidism Receiving Parathyroidectomy vs Nonoperative Management. AACE Clinical Case Reports 2021. PMID: 34842909


  21. Kim SJ, Shoback DM. Sporadic Primary Hyperparathyroidism. AACE Clinical Case Reports 2021. PMID: 34774237


  22. Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Khan AA, Levine MA, Mannstadt M, Shoback DM, Vokes TJ, Zhang P, Marelli C, Germak J, Clarke BL. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. AACE Clinical Case Reports 2021. PMID: 34801015


  23. Schafer AL, Shoback DM. A Distinction Without a Difference-Does It Matter Whether Fractures Are Nontraumatic or Traumatic? JAMA internal medicine 2021. PMID: 34096970


  24. Wysham KD, Baker JF, Shoback DM. Osteoporosis and fractures in rheumatoid arthritis. Current opinion in rheumatology 2021. PMID: 33651725


  25. Cauley JA, Shoback DM. Bone age is not just for kids. eLife 2021. PMID: 33650970


  26. Wysham KD, Shoback DM, Andrews JS, Katz PP. Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis. Bone reports 2020. PMID: 32509932


  27. Clarke BL, Shoback DM. A bridge too far? Attempting to bridge the treatment gap in osteoporosis. Endocrine 2020. PMID: 32441027


  28. Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nature metabolism 2020. PMID: 32694772


  29. Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R. Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update. The Journal of clinical endocrinology and metabolism 2020. PMID: 32068863


  30. Kim TY, Shoback DM, Black DM, Rogers SJ, Stewart L, Carter JT, Posselt AM, King NJ, Schafer AL. Increases in PYY and Uncoupling of Bone Turnover Are Associated with Loss of Bone Mass After Gastric Bypass Surgery. Bone 2019. PMID: 31689523


  31. Mannstadt M, Clarke BL, Bilezikian JP, Bone H, Denham D, Levine MA, Peacock M, Rothman J, Shoback DM, Warren ML, Watts NB, Lee HM, Sherry N, Vokes TJ. Safety and Efficacy of 5 Years of Treatment With Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism. The Journal of clinical endocrinology and metabolism 2019. PMID: 31369089


  32. Cheng Z, Li A, Tu CL, Santa Maria C, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. Calcium-sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019. PMID: 31498905


  33. Cheng C, Wentworth K, Shoback DM. New Frontiers in Osteoporosis Therapy. Annual review of medicine 2019. PMID: 31509477


  34. Wentworth K, Shoback D. Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken. JAMA internal medicine 2019. PMID: 31305872


  35. Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D. Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism 2019. PMID: 30907953


  36. Alba D, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL. Changes in lean mass, absolute and relative muscle strength, and physical performance after gastric bypass surgery. The Journal of clinical endocrinology and metabolism 2019. PMID: 30657952


  37. Cheng C, Shoback D. Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing. Current osteoporosis reports 2019. PMID: 30671884


  38. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone reports 2018. PMID: 30627599


  39. Babey M, Brandi ML, Shoback D. Conventional Treatment of Hypoparathyroidism. Endocrinology and metabolism clinics of North America 2018. PMID: 30390820


  40. Lee JY, Shoback DM. Familial hypocalciuric hypercalcemia and related disorders. Best practice & research. Clinical endocrinology & metabolism 2018. PMID: 30449544


  42. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. 2017. PMID: 29281126


  43. Vokes TJ, Mannstadt M, Levine MA, Clarke BL, Lakatos P, Chen K, Piccolo R, Krasner A, Shoback DM, Bilezikian JP. Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism. Volume 103 of Issue 2. 2018. PMID: 29099947


  44. Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM. Hypoparathyroidism. Volume 3. 2017. PMID: 28980621


  45. Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE. Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group. Volume 102 of Issue 9. 2017. PMID: 28655174


  46. Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM. Hypoparathyroidism. Volume 3. 2017. PMID: 28857066


  47. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass. Volume 32 of Issue 11. 2017. PMID: 28791737


  48. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. Volume 100 of Issue 5. 2017. PMID: 28492133


  49. Shoback D. Does parathyroid hormone control bone quality? Volume 56 of Issue 1. 2017. PMID: 28042646


  50. Clarke BL, Vokes TJ, Bilezikian JP, Shoback DM, Lagast H, Mannstadt M. Effects of parathyroid hormone rhPTH(1-84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study. Volume 55 of Issue 1. 2016. PMID: 27734257


  51. Cappola AR, Shoback DM. Osteoporosis Therapy in Postmenopausal Women With High Risk of Fracture. Volume 316 of Issue 7. JAMA 2016. PMID: 27533154


  52. Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT. Management of Hypoparathyroidism: Summary Statement and Guidelines. Volume 101 of Issue 6. 2016. PMID: 26943719


  53. Shoback DM, Bilezikian JP, Costa AG, Dempster D, Dralle H, Khan AA, Peacock M, Raffaelli M, Silva BC, Thakker RV, Vokes T, Bouillon R. Presentation of Hypoparathyroidism: Etiologies and Clinical Features. Volume 101 of Issue 6. 2016. PMID: 26943721


  54. Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Volume 49. 2015. PMID: 26688334


  55. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Volume 97 of Issue 6. 2015. PMID: 26253396


  56. Bollerslev J, Rejnmark L, Marcocci C, Shoback DM, Sitges-Serra A, van Biesen W, Dekkers OM. European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults. Volume 173 of Issue 2. 2015. PMID: 26160136


  57. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. Volume 100 of Issue 8. 2015. PMID: 26097993


  58. Shah AD, Shoback D, Lewiecki EM. Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis. Volume 7. 2015. PMID: 26082665


  59. Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. Volume 30 of Issue 8. 2015. PMID: 25640580


  60. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Volume 74. 2015. PMID: 25603463


  61. Lai JC, Shoback DM, Zipperstein J, Lizaola B, Tseng S, Terrault NA. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C. Volume 60 of Issue 6. 2015. PMID: 25563723


  62. Eastell R, Brandi ML, Costa AG, D'Amour P, Shoback DM, Thakker RV. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. Volume 99 of Issue 10. 2014. PMID: 25162666


  64. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. Volume 29 of Issue 4. 2014. PMID: 24014458


  65. Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Volume 10 of Issue 5. 2014. PMID: 24969093


  66. Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM. Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. Volume 110 of Issue 47. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 24191050


  67. Mannstadt M, Clarke BL, Vokes T, Brandi ML, Ranganath L, Fraser WD, Lakatos P, Bajnok L, Garceau R, Mosekilde L, Lagast H, Shoback D, Bilezikian JP. Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Volume 1 of Issue 4. 2013. PMID: 24622413


  68. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. Volume 28 of Issue 5. 2013. PMID: 23239173


  70. Nemeth EF, Shoback D. Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders. Volume 27 of Issue 3. 2013. PMID: 23856266


  71. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. Volume 28 of Issue 3. 2013. PMID: 23074096


  73. Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, Recker RR, Shane E, Shoback D, Potts JT. Benefits and risks of bisphosphonate therapy for osteoporosis. Volume 97 of Issue 7. 2012. PMID: 22523337


  74. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. Volume 26 of Issue 12. 2011. PMID: 21956637


  75. Prasad AP, George V, Porzig A, Horvai AE, Gross A, Shoback D, Link TM. Progressive craniofacial bone loss after cosmetic surgery at the forehead. Volume 41 of Issue 4. 2011. PMID: 22127344


  76. Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). Volume 96 of Issue 12. 2011. PMID: 21994958


  77. Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, Jüppner H, D'Amour P, Fox J, Rejnmark L, Mosekilde L, Rubin MR, Dempster D, Gafni R, Collins MT, Sliney J, Sanders J. Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. Volume 26 of Issue 10. 2011. PMID: 21812031


  78. Peacock M, Bilezikian JP, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D. Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity. Volume 96 of Issue 1. 2010. PMID: 20943783


  79. Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. Volume 95 of Issue 10. 2010. PMID: 20631026


  80. Chang W, Dvorak M, Shoback D. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Volume 484. 2010. PMID: 21036236


  81. Peacock M, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D. Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year study. Volume 94 of Issue 12. 2009. PMID: 19837909


  83. Marcocci C, Chanson P, Shoback D, Bilezikian J, Fernandez-Cruz L, Orgiazzi J, Henzen C, Cheng S, Sterling LR, Lu J, Peacock M. Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism. Volume 94 of Issue 8. 2009. PMID: 19470620


  85. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Volume 1 of Issue 35. 2008. PMID: 18765830


  86. Shoback D. Clinical practice. Hypoparathyroidism. Volume 359 of Issue 4. The New England journal of medicine 2008. PMID: 18650515


  87. Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. The Journal of clinical endocrinology and metabolism 2007. PMID: 17666472


  88. Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Volume 148 of Issue 10. 2007. PMID: 17615148


  89. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. Volume 282 of Issue 34. The Journal of biological chemistry 2007. PMID: 17591780


  90. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Volume 148 of Issue 7. 2007. PMID: 17412806


  91. Shoback D. Update in osteoporosis and metabolic bone disorders. Volume 92 of Issue 3. 2007. PMID: 17341572


  92. Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. 2006. PMID: 16728489


  93. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Volume 146 of Issue 12. 2005. PMID: 16166224


  94. Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. Extracellular Ca2+-sensing in cartilage. Journal of musculoskeletal & neuronal interactions 2004. PMID: 15758285


  95. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. Volume 90 of Issue 1. 2004. PMID: 15522938


  96. Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). Volume 279 of Issue 51. The Journal of biological chemistry 2004. PMID: 15456780


  97. Earle KE, Seneviratne T, Shaker J, Shoback D. Fanconi's syndrome in HIV+ adults: report of three cases and literature review. Volume 19 of Issue 5. 2004. PMID: 15068493


  98. Chang W, Shoback D. Extracellular Ca2+-sensing receptors--an overview. Volume 35 of Issue 3. 2004. PMID: 15200142


  99. Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. Volume 88 of Issue 12. 2003. PMID: 14671147


  100. Shattuck TM, Välimäki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. Volume 349 of Issue 18. The New England journal of medicine 2003. PMID: 14585940


  101. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Volume 59 of Issue 2. 2003. PMID: 12864795


  102. Antoniucci DM, Shoback D. Calcimimetics in the treatment of primary hyperparathyroidism. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002. PMID: 12412791


  103. Chang W, Tu C, Pratt S, Chen TH, Shoback D. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Volume 143 of Issue 4. 2002. PMID: 11897705


  104. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. The Journal of biological chemistry 2001. PMID: 11535593


  106. Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. American journal of physiology. Endocrinology and metabolism 2001. PMID: 11404236


  107. Imboden JB, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Current protocols in immunology 2001. PMID: 18432702


  108. Chang W, Chen TH, Pratt S, Shoback D. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. The Journal of biological chemistry 2000. PMID: 10764812


  109. Noor M, Shoback D. Paget's disease of bone: diagnosis and treatment update. Current rheumatology reports 2000. PMID: 11123042


  110. Chang W, Pratt S, Chen TH, Shoback D. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Molecular and cellular endocrinology 1999. PMID: 10630401


  111. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 1999. PMID: 10579354


  112. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology 1999. PMID: 10098531


  113. Khovidhunkit W, Shoback DM. Clinical effects of raloxifene hydrochloride in women. Annals of internal medicine 1999. PMID: 10068418


  114. Chang W, Chen TH, Pratt S, Shoback D. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. The American journal of physiology 1998. PMID: 9688621


  115. Loh KC, Duh QY, Shoback D, Gee L, Siperstein A, Clark OH. Clinical profile of primary hyperparathyroidism in adolescents and young adults. Clinical endocrinology 1998. PMID: 9640410


  116. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998. PMID: 9556057


  117. Loh K, Matthay KK, Hoover M, Bracho FA, Cortez AB, Conte FA, Albanese CT, Miller TR, Price DC, Flores AJ, Kaviani A, Shoback D. Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein. Hormone research 1998. PMID: 9838243


  118. Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. The American journal of physiology 1997. PMID: 9374672


  120. Chang W, Chen TH, Gardner P, Shoback D. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. The American journal of physiology 1995. PMID: 7491938


  121. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson RA. Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling. Molecular endocrinology (Baltimore, Md.) 1995. PMID: 7491116


  122. Funk JL, Shoback DM, Genant HK. Transient osteoporosis of the hip in pregnancy: natural history of changes in bone mineral density. Clinical endocrinology 1995. PMID: 7586609


  123. Shoback D, Chen TH, Pratt S, Lattyak B. Thapsigargin stimulates intracellular calcium mobilization and inhibits parathyroid hormone release. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995. PMID: 7639110


  124. Chen TH, Pratt SA, Shoback DM. Injection of bovine parathyroid poly(A)+ RNA into Xenopus oocytes confers sensitivity to high extracellular calcium. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994. PMID: 7511319


  125. Shoback DM, Chen TH, Lattyak B, King K, Johnson RM. Effects of high extracellular calcium and strontium on inositol polyphosphates in bovine parathyroid cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993. PMID: 8352071


  126. Nissenson RA, Huang Z, Blind E, Shoback D. Structure and function of the receptor for parathyroid hormone and parathyroid hormone-related protein. Receptor 1993. PMID: 8167570


  129. Membreño L, Chen TH, Woodley S, Gagucas R, Shoback D. The effects of protein kinase-C agonists on parathyroid hormone release and intracellular free Ca2+ in bovine parathyroid cells. Endocrinology 1989. PMID: 2536321


  130. Shoback DM, Membreno LA, McGhee JG. High calcium and other divalent cations increase inositol trisphosphate in bovine parathyroid cells. Endocrinology 1988. PMID: 3260174


  133. Rabinowe SL, Redgrave JE, Shoback DM, Podolsky S, Hollenberg NK, Williams GH. Renin suppression by saline is blunted in nonmodulating essential hypertension. Hypertension (Dallas, Tex. : 1979) 1987. PMID: 3308701


  134. Brown EM, Watson EJ, Thatcher JG, Koletsky R, Dawson-Hughes BF, Posillico JT, Shoback DM. Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration. Metabolism: clinical and experimental 1987. PMID: 3025550


  135. Hollenberg NK, Moore T, Shoback D, Redgrave J, Rabinowe S, Williams GH. Abnormal renal sodium handling in essential hypertension. Relation to failure of renal and adrenal modulation of responses to angiotensin II. The American journal of medicine 1986. PMID: 3752141


  136. Imboden JB, Shoback DM, Pattison G, Stobo JD. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3016713


  137. LeBoff MS, Shoback D, Brown EM, Thatcher J, Leombruno R, Beaudoin D, Henry M, Wilson R, Pallotta J, Marynick S. Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells. The Journal of clinical investigation 1985. PMID: 3965511


  139. Shoback DM, Brown EM. PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells. Biochemical and biophysical research communications 1984. PMID: 6487306


  140. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6234599


  142. Shoback DM, Thatcher J, Leombruno R, Brown EM. Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6328497


  143. Brown EM, Shoback DM. The relationship between PTH secretion and cytosolic calcium concentration in bovine parathyroid cells. Progress in clinical and biological research 1984. PMID: 6096881


  144. Shoback DM, Williams GH, Moore TJ, Dluhy RG, Podolsky S, Hollenberg NK. Defect in the sodium-modulated tissue responsiveness to angiotensin II in essential hypertension. The Journal of clinical investigation 1983. PMID: 6358261


  145. Shoback DM, Williams GH, Swartz SL, Davies RO, Hollenberg NK. Time course and effect of sodium intake on vascular and hormonal responses to enalapril (MK 421) in normal subjects. Journal of cardiovascular pharmacology 1983. PMID: 6196548


  146. Shoback DM, Williams GH, Hollenberg NK, Davies RO, Moore TJ, Dluhy RG. Endogenous angiotensin II as a determinant of sodium-modulated changes in tissue responsiveness to angiotensin II in normal man. The Journal of clinical endocrinology and metabolism 1983. PMID: 6309884


  148. Shoback D, Thatcher J, Leombruno R, Brown E. Effects of extracellular Ca++ and Mg++ on cytosolic Ca++ and PTH release in dispersed bovine parathyroid cells. Endocrinology 1983. PMID: 6861713


  149. Vlay SC, Blumenthal DS, Shoback D, Fehir K, Bulkley BH. Delayed acute myocardial infarction after blunt chest trauma in a young woman. American heart journal 1980. PMID: 7446393


  150. Shoback D. Familial cryoglobulinemia. The Johns Hopkins medical journal 1977. PMID: 859235


  151. Shoback D, Kan JA. Clinical-pathological conference. The Johns Hopkins medical journal 1977. PMID: 850338


  152. Shoback D. Pheochromocytoma. The Johns Hopkins medical journal 1976. PMID: 972438