Daniel Bikle, MD, PhD

Professor

I am Professor of Medicine and Dermatology emeritus on call back at UCSF and staff Endocrinologist at SFVAMC. I continue both my clinical activities and direct a well funded laboratory investigating hormonal regulation of fracture healing and vitamin D and calcium regulation of both skin cancer and wound response.
Education
PhD, 1974 - Graduate School of Arts and Sciences, University of Pennsylvania
MD, 1969 - School of Medicine, University of Pennsylvania
AB, 1965 - Harvard, Harvard
Honors and Awards
  • Fellowship, ASBMR, ASBMR, 2019
  • Louis V Avioli Founders Award, ASBMR, 2016
  • Career Award in Vitamin D research, International Workshop for Vitamin D, 2009
  • Boy Frame Award for Clinical Excellence in Bone and Mineral Research, ASBMR, 2007
  • member Association of American Physicians, Association of American Physicians, 1995
  • member American Society of Clinical Investigation, American Society of Clinical Investigation, 1985
  • Fellow, American College of Physicians, American College of Physicians, 1982
  • Borden Research Award, University of Pennsylvania, 1969
  • Horatio C Wood Prize in Pharmacology, University of Pennsylvania, 1969
  • Spencer Morris Prize, University of Pennsylvania, 1969
  • alpha omega alpha, University of Pennsylvania, 1968
  • Baldwin Lucke Memorial Prize, University of Pennsylvania, 1966
  • Henderson Memorial Prize in Biochemistry, Harvard, 1965
  • Magna Cum Laude, Harvard, 1965
Websites
Publications

  1. Bikle DD. Vitamin D and Long Covid: Is there a role in prevention or treatment? The Journal of clinical endocrinology and metabolism 2023. PMID: 37279939


  2. Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB. Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer. European urology oncology 2023. PMID: 37926618


  3. Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y. Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics. Communications biology 2023. PMID: 37479880


  4. Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate. The Journal of steroid biochemistry and molecular biology 2023. PMID: 37330071


  5. Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP. Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship? Reviews in endocrine & metabolic disorders 2023. PMID: 36813995


  6. Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, Cantorna MT. Highlights from the 24th workshop on vitamin D in Austin, September 2022. The Journal of steroid biochemistry and molecular biology 2023. PMID: 36639037


  7. Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D. Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2022. PMID: 36580097


  8. Mauro T, Bikle D. Skin and bone crosstalk during aging. Nature aging 2022. PMID: 37118286


  9. Bikle DD. Role of vitamin D and calcium signaling in epidermal wound healing. Journal of endocrinological investigation 2022. PMID: 35963983


  10. Seal KH, Bertenthal D, Bikle DD. Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. Journal of general internal medicine 2022. PMID: 35727478


  11. Bikle DD. Vitamin D Regulation of Immune Function. AACE Clinical Case Reports 2022. PMID: 35507293


  12. Bikle DD. Vitamin D regulation of immune function during covid-19. AACE Clinical Case Reports 2022. PMID: 35091881


  13. Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. AACE Clinical Case Reports 2022. PMID: 34981368


  14. Bikle DD. Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers. AACE Clinical Case Reports 2021. PMID: 34950833


  15. Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE. Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2021. PMID: 34230999


  16. Bikle DD. Vitamin D regulation of and by long non coding RNAs. Molecular and cellular endocrinology 2021. PMID: 34015414


  19. Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD. Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair. Endocrinology 2020. PMID: 32987403


  20. Yoshizaki K, Fukumoto S, Bikle DD, Oda Y. Transcriptional Regulation of Dental Epithelial Cell Fate. International journal of molecular sciences 2020. PMID: 33255698


  22. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings NJ, Napoli N, Accili D, Binkley N, Landry DW, Giustina A. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19. European journal of endocrinology 2020. PMID: 32755992


  23. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration. PloS one 2020. PMID: 32857768


  24. Oda Y, Bikle DD. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World journal of stem cells 2020. PMID: 32843916


  25. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling. Journal of cellular physiology 2020. PMID: 32356317


  27. Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nature reviews. Endocrinology 2020. PMID: 32029884


  28. Bikle DD. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. Journal of the Endocrine Society 2020. PMID: 32051922


  29. Bikle DD. The Vitamin D Receptor as Tumor Suppressor in Skin. Advances in experimental medicine and biology 2020. PMID: 32918224


  30. Bouillon R, Bikle D. Vitamin D metabolism revised: fall of dogmas. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019. PMID: 31589774


  31. Munson S, Wang Y, Chang W, Bikle DD. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. Journal of the Endocrine Society 2019. PMID: 31620669


  32. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and extra-skeletal actions of vitamin D: Current evidence and outstanding questions. Endocrine reviews 2018. PMID: 30321335


  33. Bikle DD. Do sunscreens block vitamin D production? A critical review by an international panel of experts. The British journal of dermatology 2019. PMID: 31259384


  34. Christakos S, Li S, De La Cruz J, Bikle DD. New developments in our understanding of vitamin metabolism, action and treatment. Metabolism: clinical and experimental 2019. PMID: 31226354


  36. Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD. The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner. JBMR plus 2019. PMID: 31667451


  37. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone reports 2018. PMID: 30627599


  38. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. The Journal of clinical endocrinology and metabolism 2018. PMID: 29955795


  39. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. British journal of clinical pharmacology 2018. PMID: 29851137


  40. Bikle DD, Bouillon R. Vitamin D and bone and beyond. Bone reports 2018. PMID: 30591929


  41. Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD. p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. Journal of cellular physiology 2018. PMID: 29923340


  42. Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair. The Journal of investigative dermatology 2018. PMID: 29787748


  43. Bikle DD. Vitamin D Assays. Frontiers of hormone research 2018. PMID: 29597233


  44. Bikle DD, Patzek S, Wang Y. Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review. Bone reports 2018. PMID: 29963603


  45. Bikle DD, Malmstroem S, Schwartz J. Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels? Endocrinology and metabolism clinics of North America 2017. PMID: 29080642


  46. Tian F, Wang Y, Bikle DD. IGF-1 signaling mediated cell-specific skeletal mechano-transduction. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017. PMID: 28980721


  47. Bikle DD. Vitamin D Prevents Sunburn: Tips for the Summer? The Journal of investigative dermatology 2017. PMID: 28941472


  48. Gallagher JC, Bikle DD. Vitamin D: Mechanisms of Action and Clinical Applications. Endocrinology and metabolism clinics of North America 2017. PMID: 29080648


  49. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. The Journal of biological chemistry 2017. PMID: 28673966


  50. Oda Y, Hu L, Nguyen T, Fong C, Tu CL, Bikle DD. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology 2017. PMID: 28368538


  51. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. Volume 100 of Issue 5. 2017. PMID: 28492133


  52. Jassil NK, Sharma A, Bikle D, Wang X. VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2017. PMID: 28095044


  53. Bikle D, Bouillon R, Thadhani R, Schoenmakers I. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? The Journal of steroid biochemistry and molecular biology 2017. PMID: 28093353


  54. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. Journal of cellular physiology 2016. PMID: 27682597


  55. Wang T, Zhang X, Bikle DD. Osteogenic Differentiation of Periosteal Cells During Fracture Healing. Journal of cellular physiology 2016. PMID: 27731505


  57. Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Frontiers in physiology 2016. PMID: 27462278


  58. Bikle DD. Extraskeletal actions of vitamin D. Annals of the New York Academy of Sciences 2016. PMID: 27649525


  59. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. BioMed research international 2016. PMID: 27340655


  61. Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD. The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle. The Journal of investigative dermatology 2016. PMID: 26994969


  62. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. The Journal of biological chemistry 2016. PMID: 26865633


  63. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. European journal of medicinal chemistry 2016. PMID: 26774929


  64. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. Journal of the American Geriatrics Society 2016. PMID: 26782853


  65. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer research 2015. PMID: 26504023


  66. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone 2015. PMID: 26453498


  67. Bikle DD. Pregnane X receptor expression in skin: the good and the bad. Experimental dermatology 2015. PMID: 26269123


  68. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015. PMID: 25801198


  69. Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD. Vitamin D and calcium regulation of epidermal wound healing. The Journal of steroid biochemistry and molecular biology 2015. PMID: 26282157


  70. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Volume 97 of Issue 6. 2015. PMID: 26253396


  71. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015. PMID: 26011431


  72. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. Volume 100 of Issue 8. 2015. PMID: 26097993


  73. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015. PMID: 25502173


  75. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Experimental dermatology 2015. PMID: 25739654


  76. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver international : official journal of the International Association for the Study of the Liver 2015. PMID: 25757956


  77. Welsh J, Bikle DD, Lips P. Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014. The Journal of steroid biochemistry and molecular biology 2015. PMID: 25641118


  78. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Canadian journal of physiology and pharmacology 2014. PMID: 25559384


  79. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. The Journal of steroid biochemistry and molecular biology 2014. PMID: 25445917


  81. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer chemotherapy and pharmacology 2014. PMID: 25107568


  82. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014. PMID: 24677183


  83. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PloS one 2014. PMID: 24949995


  84. Bikle DD, Mauro TM. Calcium, Orai1, and epidermal proliferation. The Journal of investigative dermatology 2014. PMID: 24825060


  85. Bikle D. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. The Journal of steroid biochemistry and molecular biology 2014. PMID: 24793579


  86. Jiang YJ, Bikle DD. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Experimental dermatology 2014. PMID: 24499465


  87. Hollis BW, Bikle DD. Vitamin D-binding protein and vitamin D in blacks and whites. The New England journal of medicine 2014. PMID: 24571766


  88. Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS medicinal chemistry letters 2014. PMID: 24799995


  89. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & biology 2014. PMID: 24529992


  90. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. The Journal of clinical endocrinology and metabolism 2014. PMID: 24483159


  91. Bikle DD. Vitamin D and cancer: the promise not yet fulfilled. Endocrine 2014. PMID: 24402695


  92. Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA. IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING. Nuclear receptor research 2014. PMID: 25419525


  93. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Advances in experimental medicine and biology 2014. PMID: 25207372


  94. Jiang YJ, Bikle DD. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. The Journal of steroid biochemistry and molecular biology 2013. PMID: 24342142


  95. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Frontiers in neuroendocrinology 2013. PMID: 24268499


  96. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. The Journal of steroid biochemistry and molecular biology 2013. PMID: 24240067


  97. Hu L, Bikle DD, Oda Y. Reciprocal role of vitamin D receptor on ß-catenin regulated keratinocyte proliferation and differentiation. The Journal of steroid biochemistry and molecular biology 2013. PMID: 24239508


  98. Bikle DD, Jiang Y. The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers 2013. PMID: 24202452


  99. Kubota T, Elalieh HZ, Saless N, Fong C, Wang Y, Babey M, Cheng Z, Bikle DD. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Acta astronautica 2013. PMID: 23976802


  100. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. European journal of endocrinology 2013. PMID: 24057478


  101. Wang Y, Bikle DD, Chang W. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone research 2013. PMID: 26273506


  102. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology 2013. PMID: 24048095


  103. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. The Journal of clinical endocrinology and metabolism 2013. PMID: 24030939


  104. Norman AW, Bikle D, Bouillon R. Fifteenth vitamin D workshop. The Journal of steroid biochemistry and molecular biology 2013. PMID: 23768771


  105. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 2013. PMID: 23782944


  106. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry 2013. PMID: 23713684


  107. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Volume 1287. 2013. PMID: 23682710


  108. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. Volume 28 of Issue 5. 2013. PMID: 23239173


  109. Tu CL, Bikle DD. Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best practice & research. Clinical endocrinology & metabolism 2013. PMID: 23856269


  110. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Frontiers in endocrinology 2013. PMID: 23382729


  111. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Volume 22 of Issue 2. 2013. PMID: 23362869


  112. Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2012. PMID: 22990497


  113. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part I. Journal of the American Academy of Dermatology 2012. PMID: 23062903


  114. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part II. Journal of the American Academy of Dermatology 2012. PMID: 23062904


  115. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. American journal of physiology. Endocrinology and metabolism 2012. PMID: 23047986


  116. Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A. Protective role of vitamin D signaling in skin cancer formation. The Journal of steroid biochemistry and molecular biology 2012. PMID: 23059470


  117. Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD. 1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the ß-catenin pathway. The Journal of steroid biochemistry and molecular biology 2012. PMID: 23026511


  118. Bikle DD, Xie Z, Tu CL. Calcium regulation of keratinocyte differentiation. Expert review of endocrinology & metabolism 2012. PMID: 23144648


  119. Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Current molecular pharmacology 2012. PMID: 21787292


  120. Bikle DD. Vitamin D and bone. Current osteoporosis reports 2012. PMID: 22544628


  121. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. The Journal of investigative dermatology 2012. PMID: 22622426


  122. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Science translational medicine 2012. PMID: 22623742


  123. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocrine reviews 2012. PMID: 22596255


  124. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. Journal of medicinal chemistry 2012. PMID: 22563729


  125. Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. The Journal of investigative dermatology 2012. PMID: 22495177


  126. Bikle DD. Vitamin D and the skin: Physiology and pathophysiology. Reviews in endocrine & metabolic disorders 2012. PMID: 21845365


  127. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. The Journal of investigative dermatology 2012. PMID: 22277942


  128. Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. The Journal of investigative dermatology 2011. PMID: 22189783


  129. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. Volume 26 of Issue 12. 2011. PMID: 21956637


  130. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011. PMID: 21932337


  131. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. The Journal of biological chemistry 2011. PMID: 22094462


  132. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD. Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. The Journal of investigative dermatology 2011. PMID: 21814234


  133. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011. PMID: 21312270


  134. Bikle DD. Vitamin D metabolism and function in the skin. Molecular and cellular endocrinology 2011. PMID: 21664236


  135. Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer prevention research (Philadelphia, Pa.) 2011. PMID: 21436386


  136. Tu CL, Chang W, Bikle DD. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. The Journal of investigative dermatology 2011. PMID: 21209619


  137. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Discovery medicine 2011. PMID: 21276406


  138. Bikle DD. Vitamin D regulation of immune function. Vitamins and hormones 2011. PMID: 21419265


  139. Bikle DD. Vitamin D: an ancient hormone. Experimental dermatology 2011. PMID: 21197695


  140. Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM. Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. The British journal of dermatology 2010. PMID: 20846312


  141. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. The Journal of biological chemistry 2010. PMID: 21047796


  142. Teichert A, Elalieh H, Bikle D. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice. Journal of cellular physiology 2010. PMID: 20458748


  143. Oda Y, Chalkley RJ, Burlingame AL, Bikle DD. The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation. The Journal of investigative dermatology 2010. PMID: 20520624


  144. Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y. Differential regulation of epidermal function by VDR coactivators. The Journal of steroid biochemistry and molecular biology 2010. PMID: 20298785


  145. Bikle DD. Vitamin D: newly discovered actions require reconsideration of physiologic requirements. Trends in endocrinology and metabolism: TEM 2010. PMID: 20149679


  146. Bikle DD. Vitamin D and the skin. Journal of bone and mineral metabolism 2010. PMID: 20107849


  147. Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD. Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. The Journal of investigative dermatology 2009. PMID: 20043012


  148. Bikle DD. Vitamin D and immune function: understanding common pathways. Current osteoporosis reports 2009. PMID: 19631030


  150. Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry 2009. PMID: 19183053


  151. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. Molecular biology of the cell 2009. PMID: 19158393


  152. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. The Journal of investigative dermatology 2008. PMID: 19052561


  153. Bikle D. Nonclassic actions of vitamin D. The Journal of clinical endocrinology and metabolism 2008. PMID: 18854395


  154. Bikle DD. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. The Journal of investigative dermatology 2008. PMID: 18787544


  155. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Volume 1 of Issue 35. 2008. PMID: 18765830


  156. Bikle DD. Vitamin D and the immune system: role in protection against bacterial infection. Current opinion in nephrology and hypertension 2008. PMID: 18660668


  157. Bikle DD. Growth hormone/insulin-like growth factor-1/PTH axis in bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008. PMID: 18433295


  158. Bikle DD. Integrins, insulin like growth factors, and the skeletal response to load. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008. PMID: 18373051


  160. Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007. PMID: 18290722


  161. Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL. Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. The Journal of investigative dermatology 2007. PMID: 17943182


  162. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007. PMID: 17539737


  163. Bikle DD. What is new in vitamin D: 2006-2007. Current opinion in rheumatology 2007. PMID: 17551371


  164. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Volume 148 of Issue 7. 2007. PMID: 17412806


  165. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. Journal of applied physiology (Bethesda, Md. : 1985) 2007. PMID: 17412794


  166. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. The Journal of clinical investigation 2007. PMID: 17290304


  168. Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD. Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. The Journal of steroid biochemistry and molecular biology 2007. PMID: 17223341


  169. Bikle D, Teichert A, Hawker N, Xie Z, Oda Y. Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. The Journal of steroid biochemistry and molecular biology 2007. PMID: 17229570


  170. Tu CL, Chang W, Bikle DD. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. The Journal of investigative dermatology 2006. PMID: 17124506


  171. Hawker NP, Pennypacker SD, Chang SM, Bikle DD. Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. The Journal of investigative dermatology 2006. PMID: 17082781


  172. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD. Role of IGF-I signaling in regulating osteoclastogenesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006. PMID: 16939393


  174. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology 2006. PMID: 16857753


  175. Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP. Development and progression of alopecia in the vitamin D receptor null mouse. Journal of cellular physiology 2006. PMID: 16419036


  176. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. The Journal of endocrinology 2006. PMID: 16648295


  177. Xie Z, Chang S, Oda Y, Bikle DD. Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology 2005. PMID: 16269453


  178. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Volume 146 of Issue 12. 2005. PMID: 16166224


  179. Bikle DD, Oda Y, Xie Z. Vitamin D and skin cancer: a problem in gene regulation. The Journal of steroid biochemistry and molecular biology 2005. PMID: 16039846


  181. Tu CL, Chang W, Bikle DD. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. The Journal of investigative dermatology 2005. PMID: 15654973


  182. Bikle DD. Vitamin D and skin cancer. The Journal of nutrition 2004. PMID: 15570056


  183. Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR. The effect of LXR activators on AP-1 proteins in keratinocytes. Volume 123 of Issue 1. 2004. PMID: 15191540


  184. Bikle DD. Vitamin D regulated keratinocyte differentiation. Journal of cellular biochemistry 2004. PMID: 15156556


  185. Bikle DD, Oda Y, Xie Z. Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. The Journal of steroid biochemistry and molecular biology 2004. PMID: 15225800


  186. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. The Journal of steroid biochemistry and molecular biology 2004. PMID: 15225799


  187. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation. The Journal of steroid biochemistry and molecular biology 2004. PMID: 15225784


  188. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. The Journal of investigative dermatology 2004. PMID: 15102089


  189. Tu CL, Oda Y, Komuves L, Bikle DD. The role of the calcium-sensing receptor in epidermal differentiation. Cell calcium 2004. PMID: 15200150


  190. Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003. PMID: 15040832


  191. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PTH differentially regulates expression of RANKL and OPG. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003. PMID: 14969393


  192. Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM. Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. The Journal of investigative dermatology 2003. PMID: 14632183


  193. Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcified tissue international 2003. PMID: 14565596


  194. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Molecular endocrinology (Baltimore, Md.) 2003. PMID: 12893881


  195. Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD. Skeletal unloading induces resistance to insulin-like growth factor I on bone formation. Bone 2003. PMID: 12810174


  196. Bikle DD, Sakata T, Halloran BP. The impact of skeletal unloading on bone formation. Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 2003. PMID: 12959131


  198. Dolezalova H, Shankar G, Huang MC, Bikle DD, Goetzl EJ. Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. Journal of cellular biochemistry 2003. PMID: 12577307


  199. Bikle DD, Tu CL, Xie Z, Oda Y. Vitamin D regulated keratinocyte differentiation: role of coactivators. Journal of cellular biochemistry 2003. PMID: 12520529


  200. Bikle DD, Xie Z, Ng D, Tu CL, Oda Y. Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why? Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 2003. PMID: 12899516


  201. Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM. Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro. Tissue engineering 2002. PMID: 12542939


  202. Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z. The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. Volume 119 of Issue 5. 2002. PMID: 12445200


  203. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002. PMID: 12211426


  204. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. Journal of cellular physiology 2002. PMID: 12115735


  205. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. The Journal of investigative dermatology 2002. PMID: 11851870


  206. Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. The skeletal structure of insulin-like growth factor I-deficient mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001. PMID: 11760848


  208. Tu CL, Chang W, Bikle DD. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. The Journal of biological chemistry 2001. PMID: 11500521


  209. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. Calcium- and vitamin D-regulated keratinocyte differentiation. Molecular and cellular endocrinology 2001. PMID: 11377831


  210. Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD. Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization. Journal of applied physiology (Bethesda, Md. : 1985) 2001. PMID: 11299276


  211. Hanley K, Wood L, Ng DC, He SS, Lau P, Moser A, Elias PM, Bikle DD, Williams ML, Feingold KR. Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. Journal of lipid research 2001. PMID: 11254751


  212. Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G. Selective inhibition of vitamin D hydroxylases in human keratinocytes. Steroids 2001. PMID: 11179750


  214. Kömüves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. The Journal of investigative dermatology 2000. PMID: 10951268


  215. Ng DC, Shafaee S, Lee D, Bikle DD. Requirement of an AP-1 site in the calcium response region of the involucrin promoter. The Journal of biological chemistry 2000. PMID: 10816578


  216. Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. The Journal of biological chemistry 2000. PMID: 10753967


  217. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. The Journal of investigative dermatology 2000. PMID: 10692116


  218. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. The Journal of biological chemistry 2000. PMID: 10625662


  219. Tu CL, Oda Y, Bikle DD. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes. The Journal of investigative dermatology 1999. PMID: 10469331


  220. Xie Z, Bikle DD. Phospholipase C-gamma1 is required for calcium-induced keratinocyte differentiation. The Journal of biological chemistry 1999. PMID: 10400667


  221. Bikle DD, Ettinger B, Sidney S, Tekawa IS, Tolan K. Differences in calcium metabolism between black and white men and women. Mineral and electrolyte metabolism 1999. PMID: 10436403


  222. Ratnam AV, Bikle DD, Cho JK. 1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes. Journal of cellular physiology 1999. PMID: 10048583


  223. Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E. Bone and hormonal changes induced by skeletal unloading in the mature male rat. The American journal of physiology 1999. PMID: 9886951


  224. Khoroshev MI, Munson SJ, Bikle DD. Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding. Archives of biochemistry and biophysics 1999. PMID: 9882432


  225. Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999. PMID: 9893062


  226. Bikle DD, Halloran BP. The response of bone to unloading. Journal of bone and mineral metabolism 1999. PMID: 10575587


  227. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. The Journal of biological chemistry 1998. PMID: 9722568


  228. Xie Z, Bikle DD. Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes. The Journal of investigative dermatology 1998. PMID: 9579536


  229. Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. The Journal of investigative dermatology 1998. PMID: 9540977


  231. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Molecular endocrinology (Baltimore, Md.) 1997. PMID: 9415400


  232. Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. The American journal of physiology 1997. PMID: 9435529


  233. Bikle DD. Biochemical markers in the assessment of bone disease. The American journal of medicine 1997. PMID: 9375712


  234. Bikle DD. Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation. Journal of the American Academy of Dermatology 1997. PMID: 9344184


  235. Cho JK, Bikle DD. Decrease of Ca(2+)-ATPase activity in human keratinocytes during calcium-induced differentiation. Journal of cellular physiology 1997. PMID: 9258336


  237. Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997. PMID: 9200006


  238. Bikle DD, Halloran BP, Morey-Holton E. Spaceflight and the skeleton: lessons for the earthbound. Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 1997. PMID: 11540113


  240. Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P. Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. The Journal of clinical endocrinology and metabolism 1997. PMID: 9024231


  241. Bikle DD, Halloran BP, Morey-Holton E. Space flight and the skeleton: lessons for the earthbound. The Endocrinologist 1997. PMID: 11540416


  242. Love-Schimenti CD, Gibson DF, Ratnam AV, Bikle DD. Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells. Cancer research 1996. PMID: 8665515


  243. Bikle DD, Munson S, Komuves L. Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border. The Journal of biological chemistry 1996. PMID: 8621557


  244. Bikle DD. 1,25(OH)2D3-modulated calcium induced keratinocyte differentiation. The journal of investigative dermatology. Symposium proceedings 1996. PMID: 9627687


  245. Ratnam AV, Bikle DD, Su MJ, Pillai S. Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor. The Journal of investigative dermatology 1996. PMID: 8648187


  246. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. The Journal of clinical investigation 1996. PMID: 8613532


  248. Ng DC, Su MJ, Kim R, Bikle DD. Regulation of involucrin gene expression by calcium in normal human keratinocytes. Frontiers in bioscience : a journal and virtual library 1996. PMID: 9159190


  249. Bikle DD, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S. 22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism. The Journal of investigative dermatology 1995. PMID: 7594646


  250. Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995. PMID: 8585419


  251. Pillai S, Bikle DD, Su MJ, Ratnam A, Abe J. 1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. The Journal of clinical investigation 1995. PMID: 7615834


  253. Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 1995. PMID: 7720659


  254. Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Annals of internal medicine 1995. PMID: 7872586


  255. Bikle DD, Harris J, Halloran BP, Morey-Holton E. Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation. The American journal of physiology 1994. PMID: 7810622


  256. Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994. PMID: 7863829


  257. Bikle DD, Harris J, Halloran BP, Morey-Holton ER. Skeletal unloading induces resistance to insulin-like growth factor I. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994. PMID: 7532347


  258. Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E. Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. The American journal of physiology 1994. PMID: 8074208


  259. Bikle DD. Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. Rheumatic diseases clinics of North America 1994. PMID: 7984788


  260. Bikle DD, Halloran BP, Morey-Holton E. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta astronautica 1994. PMID: 11539511


  261. Su MJ, Bikle DD, Mancianti ML, Pillai S. 1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. The Journal of biological chemistry 1994. PMID: 7910167


  262. Bikle DD, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. The Journal of investigative dermatology 1994. PMID: 8176265


  264. Bikle DD, Gee E, Pillai S. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. The Journal of investigative dermatology 1993. PMID: 8228333


  265. Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. Alcoholism, clinical and experimental research 1993. PMID: 8333602


  266. Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. The American journal of physiology 1993. PMID: 8498493


  267. Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. The Journal of clinical endocrinology and metabolism 1993. PMID: 8432789


  268. Bikle DD, Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocrine reviews 1993. PMID: 8491153


  269. Bikle DD, Munson S, Morrison N, Eisman J. Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. The Journal of biological chemistry 1993. PMID: 7678004


  270. Bikle DD. Alcohol-induced bone disease. World review of nutrition and dietetics 1993. PMID: 8367983


  271. Pillai S, Menon GK, Bikle DD, Elias PM. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. Journal of cellular physiology 1993. PMID: 8419397


  272. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. The American journal of physiology 1992. PMID: 1476189


  274. Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H. Effects of dietary protein deficiency on mineral metabolism and bone mineral density. The American journal of clinical nutrition 1992. PMID: 1636610


  275. Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. The Journal of clinical endocrinology and metabolism 1992. PMID: 1639954


  277. Pillai S, Bikle DD. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. Journal of cellular physiology 1992. PMID: 1363554


  278. Bikle DD, Pillai S, Gee E. Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect. The Journal of investigative dermatology 1991. PMID: 1875043


  279. Bikle DD, Pillai S, Gee E, Hincenbergs M. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology 1991. PMID: 1675987


  280. Bikle DD, Munson S, Mancianti ML. Limited tissue distribution of the intestinal brush border myosin I protein. Gastroenterology 1991. PMID: 1985037


  281. Pillai S, Bikle DD, Mancianti ML, Hincenbergs M. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Experimental cell research 1991. PMID: 1988295


  282. Pillai S, Bikle DD. Epidermal vitamin D metabolism, function, and regulation. Advances in lipid research 1991. PMID: 1763717


  284. Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E. Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion. The American journal of physiology 1990. PMID: 2240210


  286. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S. Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. The Journal of clinical endocrinology and metabolism 1989. PMID: 2584358


  287. Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E. Effects of simulated weightlessness on rat osteocalcin and bone calcium. The American journal of physiology 1989. PMID: 2589536


  288. Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E. Bone response to normal weight bearing after a period of skeletal unloading. The American journal of physiology 1989. PMID: 2801939


  289. Barnes PF, Modlin RL, Bikle DD, Adams JS. Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. The Journal of clinical investigation 1989. PMID: 2540219


  290. Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. The Journal of clinical investigation 1989. PMID: 2466051


  291. Halloran BP, Bikle DD, Castro ME, Gee E. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism. Biochemistry 1989. PMID: 2713363


  293. Bikle DD, Pillai S, Gee E, Hincenbergs M. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology 1989. PMID: 2463903


  294. Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P. Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins. Biochimica et biophysica acta 1989. PMID: 2909247


  295. Halloran BP, Bikle DD, Cone CM, Morey-Holton E. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. The American journal of physiology 1988. PMID: 3202163


  296. Taylor A, Bikle DD, Norman ME. Serum dihydrotachysterol levels and biological action in normal man. The Journal of clinical endocrinology and metabolism 1988. PMID: 3379133


  297. Pillai S, Bikle DD, Elias PM. 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation. The Journal of biological chemistry 1988. PMID: 2451669


  298. Pillai S, Bikle DD, Hincenbergs M, Elias PM. Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium. Journal of cellular physiology 1988. PMID: 2450102


  299. Bikle DD. Effects of alcohol abuse on bone. Comprehensive therapy 1988. PMID: 3278834


  300. Pillai S, Bikle DD, Elias PM. Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation. Skin pharmacology : the official journal of the Skin Pharmacology Society 1988. PMID: 3078531


  301. Bikle DD, Pillai S. Vitamin D metabolite production and function in keratinocytes. Annals of the New York Academy of Sciences 1988. PMID: 2470300


  302. Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM. The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro. Biochimica et biophysica acta 1987. PMID: 3040120


  303. Cunningham J, Bikle DD, Avioli LV. Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987. PMID: 3455615


  304. Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E. The effects of simulated weightlessness on bone maturation. Endocrinology 1987. PMID: 3803298


  305. Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER. Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology 1986. PMID: 3780540


  306. Long RG, Bikle DD, Munson SJ. Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum. Endocrinology 1986. PMID: 3780539


  307. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. The Journal of clinical endocrinology and metabolism 1986. PMID: 3745408


  308. Bikle DD, Gee EA, Munson SJ. Effect of ethanol on intestinal calcium transport in chicks. Gastroenterology 1986. PMID: 3743964


  309. Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. The Journal of clinical investigation 1986. PMID: 3489007


  310. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. The Journal of clinical investigation 1986. PMID: 3745436


  311. Bikle DD, Nemanic MK, Gee E, Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. The Journal of clinical investigation 1986. PMID: 2426308


  312. Bikle DD, Nemanic MK, Whitney JO, Elias PW. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry 1986. PMID: 2423114


  313. Globus RK, Bikle DD, Halloran B, Morey-Holton E. Skeletal response to dietary calcium in a rat model simulating weightlessness. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1986. PMID: 3503537


  314. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology 1986. PMID: 3485043


  315. Globus RK, Bikle DD, Morey-Holton E. The temporal response of bone to unloading. Endocrinology 1986. PMID: 3943489


  317. Bikle DD, Munson S. 1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane. The Journal of clinical investigation 1985. PMID: 3841129


  318. Bikle DD, Halloran BP, Cone CM, Morey-Holton E. Bone loss during simulated weightlessness: is it glucocorticoid mediated? The Physiologist 1985. PMID: 3834430


  319. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. The Physiologist 1985. PMID: 3841737


  320. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. The Journal of clinical endocrinology and metabolism 1985. PMID: 3840175


  321. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Annals of internal medicine 1985. PMID: 2988390


  322. Bikle DD, Halloran BP, Whitney JO, Hollis BW. Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group. Biochemistry 1984. PMID: 6543324


  324. Bikle DD, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. The Journal of clinical investigation 1984. PMID: 6549014


  325. Halloran BP, Bikle DD, Whitney JO. Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography. Journal of chromatography 1984. PMID: 6511833


  326. Bikle DD, Munson S, Chafouleas J. Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport. FEBS letters 1984. PMID: 6547914


  327. Globus RK, Bikle DD, Morey-Holton E. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology 1984. PMID: 6723581


  328. Cunningham J, Bikle DD, Avioli LV. Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism. Kidney international 1984. PMID: 6610073


  329. Bikle DD, Whitney J, Munson S. The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology 1984. PMID: 6546306


  330. Bikle DD, Munson S, Chafouleas JG. The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Progress in clinical and biological research 1984. PMID: 6549067


  332. Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER. Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton. Aviation, space, and environmental medicine 1983. PMID: 6661121


  333. Bikle DD. Fluoride treatment of osteoporosis: a new look at an old drug. Annals of internal medicine 1983. PMID: 6859684


  334. Bikle DD. Calcium absorption and vitamin D metabolism. Clinics in gastroenterology 1983. PMID: 6347462


  336. Bikle DD, Herman RH. Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion. The Journal of clinical endocrinology and metabolism 1983. PMID: 6292254


  337. Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL. Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick. Endocrinology 1982. PMID: 6896685


  338. Bikle DD. The vitamin D endocrine system. Advances in internal medicine 1982. PMID: 7041549


  340. Bikle DD, Zolock DT, Morrissey RL. Action of vitamin D on intestinal calcium transport. Annals of the New York Academy of Sciences 1981. PMID: 6951425


  341. Bikle DD, Morrissey RL, Zolock DT, Rasmussen H. The intestinal response to vitamin D. Reviews of physiology, biochemistry and pharmacology 1981. PMID: 7015459


  342. Bikle DD. Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase. Biochimica et biophysica acta 1980. PMID: 6775702


  344. Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH. Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3. Biochimica et biophysica acta 1980. PMID: 6155944


  345. Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM. Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3. Calcified tissue international 1980. PMID: 6775785


  346. Bikle DD, Morrissey RL, Zolock DT. The mechanism of action of vitamin D in the intestine. The American journal of clinical nutrition 1979. PMID: 158978


  347. Bikle DD, Morrissey RL, Zolock DT, Herman RH. Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms. The Journal of laboratory and clinical medicine 1979. PMID: 313969


  348. Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH. Work-induced muscle hypertrophy in vitamin D-deficient rats. The American journal of clinical nutrition 1979. PMID: 420144


  349. Bikle DD, Zolock DT, Morrissey RL, Herman RH. Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis. The Journal of biological chemistry 1978. PMID: 618881


  351. Morrissey RL, Empson RN, Zolock DT, Bikle DD, Bucci TJ. Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein. Biochimica et biophysica acta 1978. PMID: 620062


  353. Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR. The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus. Biochimica et biophysica acta 1977. PMID: 889896


  354. Bikle DD, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules. The Journal of clinical investigation 1975. PMID: 236326


  356. Bikle DD, Rasmussen H. A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria. Biochimica et biophysica acta 1974. PMID: 4411605


  358. Rasmussen H, Wong M, Bikle D, Goodman DB. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. The Journal of clinical investigation 1972. PMID: 4344734