Christian Vaisse, MD, PhD

Professor

Websites
Publications

  1. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Author Correction: Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nature metabolism 2024. PMID: 38429391


  2. Brewer KK, Brewer KM, Terry TT, Caspary T, Vaisse C, Berbari NF. Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain. Cells 2024. PMID: 38334651


  3. Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW. Identification of AgRP cells in the murine hindbrain that drive feeding. Molecular metabolism 2024. PMID: 38246589


  4. Terry TT, Gigante ED, Alexandre CM, Brewer KM, Engle SE, Yue X, Berbari NF, Vaisse C, Caspary T. Ciliary ARL13B prevents obesity in mice. bioRxiv : the preprint server for biology 2023. PMID: 37577625


  5. TOMAS P. BACHOR, KUSH ATTAL, EIRINI VAGENA, FRANCOIS MIFSUD, VIANA PHAM, MARTIN VALDEARCOS-CONTRERAS, CHRISTIAN VAISSE, ALLISON XU. 1522-P: Identification of AgRP Cells in the Murine Hindbrain That Drive Feeding. Diabetes 2023. PMID:


  6. Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF. Physiological Condition Dependent Changes in Ciliary GPCR Localization in the Brain. eNeuro 2023. PMID: 36849261


  7. Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. JCI insight 2023. PMID: 36692018


  8. Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. AACE Clinical Case Reports 2022. PMID: 35263131


  9. Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. The Journal of clinical investigation 2021. PMID: 33938449


  10. Adelaide A Bernard, Irene Ojeda Naharros, Florence Bourgain Guglielmetti, Xinyu Yue, Christian Vaisse. OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R. Journal of the Endocrine Society 2020. PMID:


  11. Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA. Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies. The American journal of clinical nutrition 2019. PMID: 31553429


  12. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. AACE Clinical Case Reports 2019. PMID:


  13. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nature metabolism 2019. PMID: 31535083


  14. Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science (New York, N.Y.) 2018. PMID: 30545847


  15. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Volume 50 of Issue 2. 2018. PMID: 29311635


  16. Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Volume 9 of Issue 7. 2017. PMID: 28096262


  17. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Volume 19 of Issue 11. 2017. PMID: 28614713


  18. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. The Association of Serum Leptin with Mortality in Older Adults. Volume 10 of Issue 10. PloS one 2015. PMID: 26473487


  19. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. Volume 9 of Issue 5. PloS one 2014. PMID: 24820477


  20. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Volume 22 Suppl 1. 2014. PMID: 24574081


  21. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. Functional characterization of SIM1-associated enhancers. Volume 23 of Issue 7. 2013. PMID: 24203700


  22. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Volume 38 of Issue 1. 2013. PMID: 23649472


  23. Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Volume 8 of Issue 8. Nature chemical biology 2012. PMID: 22729149


  24. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Volume 21 of Issue 7. 2011. PMID: 20957447


  25. Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Volume 19 of Issue 12. 2011. PMID: 21512513


  26. Ivy R. Aslan, Sayali A. Ranadive, Christian Vaisse. Monogenic Disorders Within the Energy Balance Pathway. Obesity Before Birth 2011. PMID:


  27. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Volume 22 of Issue 8. 2010. PMID: 20941479


  28. M.M. Swarbrick, D.S. Evans, M.I.V. Ascencio, H. Favre, S.-H. Wu, O.T. Njajou, R. Li, J.M. Zmuda, I. Miljkovic, T.B. Harris, P.-Y. Kwok, C. Vaisse, W.-C. Hsueh. Systematic examination of the SIM1 gene region: Replication and extension of association between common genetic variants and adiposity. Obesity Research & Clinical Practice 2010. PMID:


  29. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. Bariatric surgery in a patient with complete MC4R deficiency. Volume 35 of Issue 3. 2010. PMID: 20733581


  30. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Volume 46 of Issue 1. 2009. PMID: 19853069


  31. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. Volume 23 of Issue 9. 2009. PMID: 19417090


  32. Calton MA, Vaisse C. Narrowing down the role of common variants in the genetic predisposition to obesity. Volume 1 of Issue 3. 2009. PMID: 19341502


  33. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Volume 71 of Issue 3. 2008. PMID: 19170711


  34. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Volume 18 of Issue 6. 2008. PMID: 19091795


  35. Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. Volume 93 of Issue 12. 2008. PMID: 18765507


  36. Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Volume 37 of Issue 3. 2008. PMID: 18775361


  37. Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Volume 63 of Issue 2. 2008. PMID: 18091355


  38. Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Volume 10 of Issue 10. 2007. PMID: 18093211


  39. Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. Volume 2 of Issue 7. PloS one 2007. PMID: 17668051


  40. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA. Medical sequencing at the extremes of human body mass. Volume 80 of Issue 4. 2007. PMID: 17357083


  41. B Dubern, C Lubrano-berthelier, D Bouglé, ML Frelut, C Simon, C Vaisse, K Clément, P Tounian. MUTATIONAL ANALYSIS OF THE PROOPIOMELANOCORTIN GENE IN OBESE CHILDREN. Journal of pediatric gastroenterology and nutrition 2006. PMID:


  42. Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. Volume 91 of Issue 5. 2006. PMID: 16507637


  43. Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Volume 26 of Issue 10. 2005. PMID: 16083993


  44. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. Lack of support for the association between GAD2 polymorphisms and severe human obesity. Volume 3 of Issue 9. 2005. PMID: 16122350


  45. Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. Volume 90 of Issue 8. 2005. PMID: 15914531


  46. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Volume 434 of Issue 7032. 2005. PMID: 15724149


  47. Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ. A statistical approach for array CGH data analysis. Volume 6. 2005. PMID: 15705208


  48. Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PAX4 gene variations predispose to ketosis-prone diabetes. Volume 13 of Issue 24. 2004. PMID: 15509590


  49. Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. Volume 114 of Issue 8. The Journal of clinical investigation 2004. PMID: 15489963


  50. Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C. A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. Volume 89 of Issue 5. 2004. PMID: 15126516


  51. Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Volume 53 of Issue 3. 2004. PMID: 14988248


  52. Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C. The human MC4R promoter: characterization and role in obesity. Volume 52 of Issue 12. 2003. PMID: 14633862


  53. Swarbrick MM, Vaisse C. Emerging trends in the search for genetic variants predisposing to human obesity. Volume 6 of Issue 4. 2003. PMID: 12806208


  54. Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Volume 994. 2003. PMID: 12851320


  55. Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. Molecular genetics of human obesity-associated MC4R mutations. Volume 994. 2003. PMID: 12851297


  56. Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Volume 12 of Issue 2. 2003. PMID: 12499395


  57. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS. Elevated plasma ghrelin levels in Prader Willi syndrome. Volume 8 of Issue 7. Nature medicine 2002. PMID: 12091883


  58. Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. Volume 50 of Issue 6. 2000. PMID: 10899756


  59. Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Volume 49 of Issue 8. 2000. PMID: 10923636


  60. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Volume 106 of Issue 2. The Journal of clinical investigation 2000. PMID: 10903341


  61. Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Volume 24 of Issue 3. 2000. PMID: 10757637


  62. Mueller MD, Vigne JL, Vaisse C, Taylor RN. Glycodelin: a pane in the implantation window. Volume 18 of Issue 3. 2000. PMID: 11299967


  63. Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. Volume 83 of Issue 11. 1998. PMID: 9814484


  64. Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Volume 20 of Issue 2. 1998. PMID: 9771699


  65. Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Volume 392 of Issue 6674. 1998. PMID: 9537324


  68. Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Volume 14 of Issue 1. 1996. PMID: 8782827


  69. Ruiz J, Blanché H, James RW, Garin MC, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P. Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Volume 346 of Issue 8979. Lancet (London, England) 1995. PMID: 7564671


  70. Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Volume 333 of Issue 6. The New England journal of medicine 1995. PMID: 7609752


  71. Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Volume 9 of Issue 3. 1995. PMID: 7773293


  72. Mellon SH, Kushner JA, Vaisse C. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. Volume 10 of Issue 5. 1991. PMID: 1863358


  73. Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A. The human placental protein 14 (PP14) gene is localized on chromosome 9q34. Volume 86 of Issue 5. 1991. PMID: 2016092


  74. Vaisse C, Atger M, Potier B, Milgrom E. Human placental protein 14 gene: sequence and characterization of a short duplication. Volume 9 of Issue 6. 1990. PMID: 2206398


  75. Mellon SH, Vaisse C. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Volume 86 of Issue 20. Proceedings of the National Academy of Sciences of the United States of America 1989. PMID: 2554289