The Journal of clinical investigation
Unveiling the proteome-wide autoreactome enables enhanced evaluation of emerging CAR-T therapies in autoimmunity.
Rare neutralizing IFN-γ autoantibodies in HLA-DRB1* 15:02 or 16:02 individuals confer susceptibility to mycobacterial infections.
Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs.
Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.
Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney.
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes.
Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
